Hayhurst M, Braude A, Benatar S R
S Afr Med J. 1978 Feb 18;53(7):259-60.
Two asthmatic patients with life-threatening allergy to intravenous hydrocortisone are described. A 21-year-old woman with chronic atopic asthma developed severe bronchospasm on 3 occasions after treatment with hydrocortisone. Allergy to hydrocortisone was only established on the third occasion. Skin prick tests with hydrocortisone (Solu-Cortef) gave a 5-mm wheal reaction and confirmed the allergy. Skin prick tests with methylprednisolone and dexamethasone elicited no allergic response. Allergy to hydrocortisone was also seen on 2 occasions in a 41-year-old man with asthma, although it was not proved by challenging him with intravenous hydrocortisone.
本文描述了两名对静脉注射氢化可的松有危及生命过敏反应的哮喘患者。一名21岁患有慢性特应性哮喘的女性在接受氢化可的松治疗后3次出现严重支气管痉挛。对氢化可的松的过敏仅在第三次才得以确诊。用氢化可的松（氢化可的松注射液）进行皮肤点刺试验出现了5毫米的风团反应，证实了过敏。用甲泼尼龙和地塞米松进行皮肤点刺试验未引发过敏反应。一名41岁的哮喘男性也有2次出现对氢化可的松的过敏反应，不过未通过静脉注射氢化可的松激发试验加以证实。
