Successful renal transplantation in a patient with anaphylactic reaction to Solu-Medrol (methylprednisolone sodium succinate).

Following the intravenous infusion of Solu-Medrol (methylprednisolone sodium succinate), anaphylactic shock developed in a 41 year old man on two consecutive occasions, six weeks apart. Intracutaneous testing with different components of he Solu-Medrol Mix-O-Vial demonstrated that the patient was allergic to methylprednisolone sodium succinate but not to other ingredients. In view of the recent increase in the popularity of steroid pulse therapy, we believe that all clinicians should be aware of this unusual and potentially fatal reaction to Solu-Medrol.