Saga T, Said S I
Trans Assoc Am Physicians. 1984;97:304-10.
VIP, an endogenous neuropeptide normally present in lungs and other organs, relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma in vitro. Pretreatment of these tissues with indomethacin (1 micrograms/ml) markedly enhances the basal tone and the relaxant effect of VIP. The VIP-induced relaxation, especially of pulmonary artery, has a long duration. As a relaxant of human pulmonary arterial strip, VIP is approximately 200 times as potent as prostacyclin, on a molar basis. The results suggest a possible role for VIP as a modulator of airway and pulmonary vascular tone, and as a potential bronchodilator and pulmonary vasodilator in human subjects.
血管活性肠肽（VIP）是一种内源性神经肽，正常存在于肺和其他器官中，在体外可使分离的人支气管、肺动脉和肺实质条带舒张。用吲哚美辛（1微克/毫升）预处理这些组织可显著增强基础张力以及VIP的舒张作用。VIP诱导的舒张，尤其是对肺动脉的舒张，持续时间较长。作为人肺动脉条带的舒张剂，按摩尔计算，VIP的效力约为前列环素的200倍。这些结果表明，VIP可能作为气道和肺血管张力的调节剂，以及作为人类受试者潜在的支气管扩张剂和肺血管扩张剂发挥作用。
