由单克隆抗体界定的小鼠畸胎癌干细胞的分化抗原
Differentiation antigens of mouse teratocarcinoma stem cells defined by monoclonal antibodies.
作者信息
Dráber P, Pokorná Z
出版信息
Cell Differ. 1984 Dec;15(2-4):109-13. doi: 10.1016/0045-6039(84)90060-5.
Three differentiation antigens of mouse teratocarcinoma stem cells are defined using a panel of ten IgM-class monoclonal antibodies raised against teratocarcinoma F9 cells. TEC-01 and four other antibodies define an antigen that corresponds to SSEA-1. TEC-02 antibody defines an antigen that is expressed on teratocarcinoma stem cells, parietal yolk sac cells PYS-2, unfertilized eggs including the zona pellucida and blastocysts. It is absent from all mouse adult tissues tested. Three other antibodies exhibit binding properties similar to TEC-02. TEC-03 antibody defines an antigen that is expressed on teratocarcinoma stem cells, PYS-2 cells and mouse blastocysts. It is absent from all mouse adult tissues except for lungs.
利用一组针对畸胎瘤F9细胞产生的十种IgM类单克隆抗体，确定了小鼠畸胎瘤干细胞的三种分化抗原。TEC-01和其他四种抗体确定了一种与阶段特异性胚胎抗原-1（SSEA-1）相对应的抗原。TEC-02抗体确定了一种在畸胎瘤干细胞、壁层卵黄囊细胞PYS-2、包括透明带和囊胚在内的未受精卵上表达的抗原。在所有测试的小鼠成年组织中均未发现该抗原。其他三种抗体表现出与TEC-02相似的结合特性。TEC-03抗体确定了一种在畸胎瘤干细胞、PYS-2细胞和小鼠囊胚上表达的抗原。除肺外，在所有小鼠成年组织中均未发现该抗原。
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