Elyan A, Mahran M, el-Maraghy M, Abou-Seeda M
Chemioterapia. 1984 Feb;3(1):67-70.
Prophylactic chemotherapy was given to 100 patients who underwent cesarean section. Ampicillin was given to 50 patients and I.V. metronidazole to the other 50 (in a single dose of 500 mg to 20 and in 3 doses to 30 patients). The overall febrile morbidity was 20%. Metronidazole was superior in reducing febrile morbidity and wound sepsis, compared to ampicillin (P less than 0.05). This study supports the concept of prophylactic chemotherapy being beneficial to the obstetric patient. A single dose of 500 mg I.V. is satisfactory for prophylactic use in cesarean section.
对100例行剖宫产的患者进行了预防性化疗。50例患者给予氨苄西林，另外50例给予静脉注射甲硝唑（20例单次剂量为500mg，30例分3次给药）。总体发热发病率为20%。与氨苄西林相比，甲硝唑在降低发热发病率和伤口感染方面更具优势（P<0.05）。本研究支持预防性化疗对产科患者有益的观点。静脉注射单次剂量500mg用于剖宫产的预防性使用是令人满意的。
