Katsulov A, Pŭnevska M
Akush Ginekol (Sofiia). 1989;28(6):33-7.
The effect of a single prophylactic dose of 500 mg of doxacycline was studied on infectious morbidity in 50 women, undergone caesarean section. There was a reduction in the number of women with puerperal infection in comparison with a control group of women, who received long regimen of prophylactic antibiotics--ampicillin and gentamicin. The reduction was manifested mostly in women with endometritis and febrile state. It is suggested that this could be due to long-lasting monotonous prophylaxis, causing resistance of the microorganisms.
研究了单次预防性给予500毫克多西环素对50例行剖宫产的女性感染发病率的影响。与接受长期预防性抗生素(氨苄西林和庆大霉素)治疗的女性对照组相比,产褥感染的女性数量有所减少。这种减少主要表现在患有子宫内膜炎和发热状态的女性中。有人认为,这可能是由于长期单一的预防措施导致微生物产生耐药性所致。