Yamada M
Nihon Heikatsukin Gakkai Zasshi. 1984 Dec;20(6):483-91. doi: 10.1540/jsmr1965.20.483.
The effects of prostaglandin (PG) F2 alpha and E2 on the denervated smooth muscle of the urinary bladder in female rats were studied in vivo by histochemistry and electron microscopy. The urinary bladder denervated by bilateral removal of the pelvic ganglion was markedly distended, being filled with urine. Daily intravenous administration of PGF2 alpha or PGE2 for 6 days following the operation showed that rats receiving PGE2 urinated remarkably more than those receiving PGF2 alpha. But the ultrastructural changes on the smooth muscle cells, such as dilated tubules of rough endoplasmic reticulum and large Golgi vacuoles, were more prominent in the PGF2 alpha administrated urinary bladders than in PGE2 administrated ones. On occasion, cholinergic ganglion cells happened to be encountered in the muscular layer of a rat urinary bladder. These intramural ganglion cells and the cholinergic nerve fibers surrounding the cells displayed strong acetylcholinesterase activity, unaffected by bilateral pelvic ganglionectomy.
通过组织化学和电子显微镜技术，在体内研究了前列腺素（PG）F2α和E2对雌性大鼠去神经支配膀胱平滑肌的影响。通过双侧切除盆腔神经节使膀胱去神经支配后，膀胱明显扩张，充满尿液。术后连续6天每日静脉注射PGF2α或PGE2，结果显示接受PGE2的大鼠排尿量明显多于接受PGF2α的大鼠。但是，与接受PGE2的膀胱相比，接受PGF2α的膀胱中平滑肌细胞的超微结构变化更明显，如粗面内质网扩张的小管和大的高尔基体空泡。偶尔，在大鼠膀胱肌层中会遇到胆碱能神经节细胞。这些壁内神经节细胞及其周围的胆碱能神经纤维显示出强烈的乙酰胆碱酯酶活性，不受双侧盆腔神经节切除术的影响。
