Tomashefski J F, Oppermann H C, Vawter G F, Reid L M
Pediatr Pathol. 1984;2(4):469-87. doi: 10.3109/15513818409025895.
Using morphometry, the pulmonary vasculature in lungs obtained at autopsy from 8 patients with bronchopulmonary dysplasia (BPD) was studied. In these specimens the axial arterial pathway was similar in length to those of equivalently aged fetuses and increased with lengthening survival. The internal diameter of axial arteries was variable--excessively wide in 2 patients and diffusely narrow in 3. Microscopically, the percent medial thickness of muscular pulmonary arteries was reduced compared to fetal values and tended to be less in older patients. Compared to normal fetuses, there were more muscularized intraacinar arteries, suggesting peripheral extension of smooth muscle. Arterial concentrations were elevated in 2 long-term survivors. The weight of the cardiac right ventricle was reduced in 4 patients. These findings indicate that in patients with BPD there is a complex dual process of pathological remodeling and an attempt at normal anatomic adaptation of the pulmonary vasculature to extrauterine life.
利用形态测量法，对8例支气管肺发育不良（BPD）患者尸检获得的肺脏中的肺血管系统进行了研究。在这些标本中，轴向动脉路径的长度与同龄胎儿相似，并随存活时间延长而增加。轴向动脉的内径各不相同——2例患者的动脉内径过宽，3例患者的动脉内径弥漫性变窄。显微镜下，与胎儿值相比，肌性肺动脉的中膜厚度百分比降低，且在年龄较大的患者中往往更低。与正常胎儿相比，腺泡内动脉肌化程度更高，提示平滑肌向周边延伸。2例长期存活者的动脉浓度升高。4例患者右心室重量减轻。这些发现表明，BPD患者存在复杂的双重病理重塑过程，以及肺血管系统试图对宫外生活进行正常解剖学适应的过程。
