Martin C J, Hynynen K, Watmough D J
Ultrasound Med Biol. 1984 Nov-Dec;10(6):701-8. doi: 10.1016/0301-5629(84)90229-1.
Thermocouple junctions coated with absorbing material have been used for measurement of ultrasound energy density distribution in vivo. The response of this type of probe has been measured in tumours implanted in rats, in ox liver, and in a water bath, using 1 and 3 MHz focussed ultrasound, and these measurements are reported in this paper. The initial rapid rate of temperature rise during the first 60 ms after the ultrasound is switched on provides a reliable index of ultrasound energy density. The coating material increases the magnitude of the temperature rise and reduces variations caused by differences in tissue properties and changes in blood flow. The response is a linear function of ultrasound energy density over the range of interest for therapeutic applications. Thus probes calibrated in known ultrasound fields in water tanks can be used to estimate energy densities in tissue directly.
涂有吸收材料的热电偶结已用于体内超声能量密度分布的测量。使用1兆赫和3兆赫聚焦超声，在植入大鼠的肿瘤、牛肝和水浴中测量了这种探头的响应，并在本文中报告了这些测量结果。超声开启后的前60毫秒内初始快速升温速率提供了超声能量密度的可靠指标。涂层材料增加了升温幅度，并减少了由组织特性差异和血流变化引起的变化。在治疗应用感兴趣的范围内，响应是超声能量密度的线性函数。因此，在水箱中已知超声场中校准的探头可直接用于估计组织中的能量密度。
