Sinclair J D
Alcohol. 1984 May-Jun;1(3):223-7. doi: 10.1016/0741-8329(84)90102-2.
A single injection of 2.5 g/kg ethanol one hr after drinking a 10% ethanol-0.05% saccharin solution produced a persistent conditioned taste aversion to the ethanol-saccharin solution. Twelve pairings produced a still stronger aversion that generalized to an aversion to a 10% ethanol solution without saccharin. Unpaired presentations of ethanol-saccharin solution and ethanol injections prevented the subsequent development of an aversion from a single pairing. Twelve pairings of access to saccharin solution with ethanol injections produced an aversion that generalized to an ethanol-saccharin solution. All groups receiving 12 alternate-day ethanol injections developed tolerance to the hypothermic effect of ethanol, but the tolerance was not conditioned to the drinking fluids previously paired with ethanol injections and it was unrelated to the subsequent drinking behaviors.
在饮用10%乙醇-0.05%糖精溶液1小时后单次注射2.5克/千克乙醇，会产生对乙醇-糖精溶液持续的条件性味觉厌恶。十二次配对产生了更强的厌恶，这种厌恶泛化到对不含糖精的10%乙醇溶液的厌恶。乙醇-糖精溶液和乙醇注射的非配对呈现阻止了随后单次配对产生的厌恶的发展。糖精溶液饮用与乙醇注射的十二次配对产生了一种泛化到乙醇-糖精溶液的厌恶。所有接受隔日乙醇注射12次的组对乙醇的体温过低效应产生了耐受性，但这种耐受性并未与先前与乙醇注射配对的饮用液体形成条件联系，且与随后的饮用行为无关。
