Kawamura K, Naito J
Neurosci Res. 1984 Apr;1(2):89-103. doi: 10.1016/s0168-0102(84)80007-3.
The corticocortical afferents innervating the prefrontal cortex in the monkey were studied by means of the retrograde axonal transport of horseradish peroxidase. After injection of small amounts (0.3-0.5 microliter) of this enzyme into various parts of the prefrontal cortex, many labeled neurons (mostly pyramids of 15-25 microns in diameter) were found in various cortical regions of the ipsilateral hemisphere. A small part of the prefrontal cortex received fibers from other parts of the same cortex. For example, area 8 receives many fibers from both the rostral part of area 9 and a small area adjacent to the inferior branch of the arcuate sulcus. On the other hand, area 9 in the inferior prefrontal convexity receives fibers from localized parts of areas 8 and 9 in the dorsolateral convexity as well as from area 6. It is also apparent that association connections from the dorsolateral to the inferior convexity are stronger than those going in the opposite direction. The prefrontal afferents from other cortical regions include many fibers originating from the posterior association cortex as well as some fibers arising in the cingulate and orbital gyri. The prefrontal cortex does not receive direct corticocortical fibers from the motor and "primary" sensory cortices. There is a topographic pattern in the prefrontal projections from the cortical walls (STs area) surrounding the superior temporal sulcus. Thus, the caudal half of the STs area projects to area 8 and a small adjacent part of area 9. The dorsal wall of the rostral half of the STs area projects to areas 9-12, the fundus to the inferior convexity, and the ventral wall only to the caudal part of the convexity. Projections from the circumjacent association cortex of the STs area to the prefrontal cortex as well as to the STs area are likewise found to be topographically organized. This suggests that certain parts of the posterior association cortex projecting to particular areas of the prefrontal cortex, also send fibers to those parts of the STs area which project to the same prefrontal areas.
运用辣根过氧化物酶逆行轴突运输法，对支配猕猴前额叶皮质的皮质-皮质传入神经进行了研究。将少量（0.3 - 0.5微升）这种酶注入前额叶皮质的不同部位后，在同侧半球的各个皮质区域发现了许多标记神经元（大多是直径为15 - 25微米的锥体神经元）。前额叶皮质的一小部分接受来自同一皮质其他部位的纤维。例如，8区接受来自9区吻侧部分以及与弓状沟下支相邻的一个小区域的许多纤维。另一方面，前额叶下部凸面的9区接受来自背外侧凸面8区和9区局部区域以及6区的纤维。同样明显的是，从背外侧到下部凸面的联合连接比相反方向的连接更强。来自其他皮质区域的前额叶传入神经包括许多起源于后联合皮质的纤维以及一些起于扣带回和眶回的纤维。前额叶皮质不接受来自运动皮质和“初级”感觉皮质的直接皮质-皮质纤维。围绕颞上沟的皮质壁（颞上沟区）的前额叶投射存在拓扑模式。因此，颞上沟区的后半部分投射到8区和9区相邻的一小部分。颞上沟区前半部分的背壁投射到9 - 12区，底部投射到下部凸面，腹侧壁仅投射到凸面的尾侧部分。同样发现，颞上沟区相邻联合皮质向前额叶皮质以及向颞上沟区的投射也是按拓扑方式组织的。这表明，投射到前额叶皮质特定区域的后联合皮质的某些部分，也向颞上沟区中投射到相同前额叶区域的那些部分发送纤维。
