Heilmann E, Riad F, Achatzy R, Hewing R, Dittrich H, Bender F
Thoraxchir Vask Chir. 1978 Apr;26(2):104-8. doi: 10.1055/s-0028-1096605.
In 20 patients, suffering from various diseases, the extent of haemolysis and the correlation between the rate of haemolysis and various mechanisms of erythrocyte damage in the course of open heart surgery was studied. We investigated haemotological parameters, electrolytes, lactate dehydrogenase before, and 1, 3, 5, and 7 days after operation. Besides free haemoglobin, haptoglobin and haemopexin were determined 5 and 15 minutes after starting perfusior with the heart-lung machine and after finishing. The best index of haemolysis was free haemoglobin in the serum. With increasing duration of perfusion the rate of haemolysis increased. Compensating mechanisms were postoperative increase of haptoglobin and haemopexin.
在20例患有各种疾病的患者中，研究了心脏直视手术过程中的溶血程度以及溶血速率与红细胞损伤各种机制之间的相关性。我们在手术前以及术后第1、3、5和7天调查了血液学参数、电解质、乳酸脱氢酶。此外，在心肺机开始灌注后5分钟和15分钟以及灌注结束后，测定了游离血红蛋白、触珠蛋白和血红素结合蛋白。溶血的最佳指标是血清中的游离血红蛋白。随着灌注时间的延长，溶血速率增加。代偿机制是术后触珠蛋白和血红素结合蛋白增加。
