George F, Chu N S
Alcohol. 1984 Sep-Oct;1(5):353-8. doi: 10.1016/0741-8329(84)90002-8.
The effects of ethanol on rat cerebellar Purkinje cells were studied using brain slice preparations. The spontaneous activity of Purkinje cells exhibited either steady or cyclic firing patterns. The steady units were generally inhibited by ethanol, but some units were excited by low doses. The cycling units showed a dose-related decrease in firing rate and the duration of cyclic firing. The data indicate that ethanol in concentrations which produce behavioral effects is primarily inhibitory to cerebellar Purkinje cells.
利用脑片制备技术研究了乙醇对大鼠小脑浦肯野细胞的影响。浦肯野细胞的自发活动表现出稳定或周期性放电模式。稳定的细胞单位通常受到乙醇的抑制，但一些细胞单位在低剂量时会被兴奋。周期性放电的细胞单位的放电频率和放电周期持续时间呈剂量依赖性降低。数据表明，产生行为效应浓度的乙醇主要对小脑浦肯野细胞具有抑制作用。
