Carpanini F M, Gaunt I F, Hardy J, Gangolli S D, Butterworth K R, Lloyd A G
Toxicology. 1978 Feb;9(1-2):29-45. doi: 10.1016/0300-483x(78)90029-x.
Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all treatment levels in both sexes, while growth and food consumption were reduced in both sexes given 800 ppm and in males give 200 ppm. Males given 100 ppm or above and females given 200 or 800 ppm produced less urine than the controls in a period without water or following a water load. The only changes in organ weight that could be attributed to treatment were increased values for the relative weights of liver, spleen and kidney. All 3 organs were affected in both sexes given 800 ppm and the kidneys were also affected in both sexes given 200 ppm and in females given 100 ppm. No effects attributable to allyl alcohol treatment were seen at autopsy or in the histopathological examination. The no-untoward-effect level established in this study was 50 ppm of the drinking water, a level equivalent to an intake in rats of between 4.8 and 6.2 mg allyl alcohol/kg/day.
将15只雄性和15只雌性大鼠分为几组，分别给予饮用水中0（对照）、50、100、200或800 ppm的烯丙醇，持续15周。血液学检查或血清分析结果中未发现烯丙醇有任何影响。在所有处理水平下，两性的液体摄入量均呈剂量相关减少，而给予800 ppm的两性以及给予200 ppm的雄性的生长和食物消耗量均减少。在禁水期或水负荷后，给予100 ppm及以上的雄性和给予200或800 ppm的雌性产生的尿液比对照组少。唯一可归因于处理的器官重量变化是肝脏、脾脏和肾脏相对重量值增加。给予800 ppm的两性所有这3个器官均受影响，给予200 ppm的两性以及给予100 ppm的雌性的肾脏也受影响。尸检或组织病理学检查未发现烯丙醇处理有任何影响。本研究确定的无不良影响水平为饮用水中50 ppm，该水平相当于大鼠摄入烯丙醇4.8至6.2 mg/kg/天。
