一例白塞病合并膜性肾病。

A case of Behçet's disease associated with membranous nephropathy.

作者信息

Miura M, Tomino Y, Suga T, Endoh M, Nomoto Y, Sakai H, Furuya K, Kobayashi Y

出版信息

Tokai J Exp Clin Med. 1984 Aug;9(3):231-5.

Abstract

A 35-year-old female patient with Behçet's disease associated with nephrotic syndrome is described. Renal biopsy specimens revealed typical features of membranous nephropathy in light microscopical, electron microscopical and immunofluorescent microscopical examinations. Circulating immune complexes (IC) phagocytized by polymorphonuclear leukocytes (PMN) in this patient were significantly increased compared with those in healthy adults. Recurrent oral aphthous ulcers had persisted for 14 years. In the course of Behçet's disease, nephrotic syndrome due to membranous nephropathy was observed. Depositions of IgA, IgM, C3 and C4 were observed in the subcutaneous arteriolar walls by immunofluorescence. It is suggested that the pathogenesis of Behçet's disease and membranous nephropathy might be due to a deposition of circulating immune complexes in various types of vascular vessels in this patient.

摘要

本文描述了一名35岁患有白塞病并伴有肾病综合征的女性患者。肾活检标本在光学显微镜、电子显微镜和免疫荧光显微镜检查中显示出膜性肾病的典型特征。与健康成年人相比，该患者中被多形核白细胞（PMN）吞噬的循环免疫复合物（IC）显著增加。复发性口腔溃疡已持续14年。在白塞病病程中，观察到了由膜性肾病引起的肾病综合征。通过免疫荧光在皮下小动脉壁中观察到了IgA、IgM、C3和C4的沉积。提示该患者白塞病和膜性肾病的发病机制可能是由于循环免疫复合物在各种血管中的沉积。