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人类精子速度及授精后宫颈黏液检测在不育夫妇评估中的应用

Human sperm velocity and postinsemination cervical mucus test in the evaluation of the infertile couple.

作者信息

Beauchamp P J, Galle P C, Blasco L

出版信息

Arch Androl. 1984;13(2-3):107-12. doi: 10.3109/01485018408987508.

DOI:10.3109/01485018408987508
PMID:6537738
Abstract

Homologous artificial insemination (AIH) followed by postinsemination cervical mucus test (PIT) was performed in 100 couples in a prospective study to evaluate suspected cervical or male factor infertility. A portion of the ejaculate was submitted for standard semen analysis as well as turbidimetric analysis of sperm velocity. In a review of 333 cases evaluated for infertility, the average sperm velocity in a normal semen analysis was 96.5 mu/sec, for those with normal postcoital test (PCT) 96.6 mu/sec, and in those that established a pregnancy 91.6 mu/sec. These are significantly higher than the values obtained for abnormal semen analysis and abnormal PCT (64.6 and 63.6 mu/sec, respectively; p less than 0.001). Patients with normal PIT (WHO criteria for normal PCT consisting of greater than or equal to 7 motile sperm/hpf) had sperm velocity of 87 mu/sec compared to velocities of 46 mu/sec for abnormal PIT (p less than 0.001). Four of the five patients with abnormal PIT (in spite of normal semen analysis and normal cervical mucus) had sperm velocities less than 75 mu/sec. Likewise, all 8 patients who had normal PIT in spite of abnormal semen analysis had sperm velocities greater than 75 mu/sec, even though the sperm motility was below normal in 5 of them. Sperm velocity is a more sensitive indicator of sperm function when compared to standard semen analysis results.

摘要

在一项前瞻性研究中,对100对夫妇进行了同种异体人工授精(AIH),随后进行授精后宫颈黏液测试(PIT),以评估疑似宫颈或男性因素导致的不孕症。将一部分精液用于标准精液分析以及精子速度的比浊法分析。在对333例不孕症评估病例的回顾中,正常精液分析中的平均精子速度为96.5微米/秒,性交后试验(PCT)正常者为96.6微米/秒,而成功受孕者为91.6微米/秒。这些值显著高于精液分析异常和PCT异常者所获得的值(分别为64.6和63.6微米/秒;p<0.001)。PIT正常的患者(WHO正常PCT标准为每高倍视野活动精子≥7个)精子速度为87微米/秒,而PIT异常者为46微米/秒(p<0.001)。PIT异常的5例患者中有4例(尽管精液分析和宫颈黏液正常)精子速度低于75微米/秒。同样,尽管精液分析异常但PIT正常的所有8例患者精子速度均大于75微米/秒,其中5例精子活力低于正常水平。与标准精液分析结果相比,精子速度是精子功能更敏感的指标。

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