相移对大鼠脑不同区域单胺氧化酶活性随年龄变化的影响。

Effect of phase shift on monoamine oxidase activity in different regions of the rat brain as a function of age.

作者信息

Bhaskaran D, Radha E

出版信息

J Gerontol. 1984 Jan;39(1):22-9. doi: 10.1093/geronj/39.1.22.

DOI:10.1093/geronj/39.1.22

Abstract

The effect of reversed light-dark cycle on the monoamine oxidase activity of different regions of the rat brain in various age groups was studied. Twenty-one-day-old rats showed an irregular pattern of shift in the appearance of the peak activity. In the case of 3-, 6-, and 12-month-old rats, all the regions of the brain became synchronized to the altered environmental condition, and the peak MAO activity was shifted by 180 degrees. In the cerebral cortex of 24-month-old rats the peak was shifted by only 60 degrees, whereas a 120 degrees shift was observed for all the other regions. The present study suggests that the synchronizing effect of the light-dark cycle is age dependent.

摘要

研究了颠倒的明暗周期对不同年龄组大鼠脑不同区域单胺氧化酶活性的影响。21日龄大鼠的峰值活性出现呈现不规则的变化模式。对于3个月、6个月和12个月大的大鼠，脑的所有区域都与改变后的环境条件同步，单胺氧化酶活性峰值偏移了180度。在24个月大的大鼠的大脑皮层中，峰值仅偏移了60度，而其他所有区域则观察到120度的偏移。本研究表明，明暗周期的同步作用是年龄依赖性的。