Saxon A, Hassner A, Swabb E A, Wheeler B, Adkinson N F
J Infect Dis. 1984 Jan;149(1):16-22. doi: 10.1093/infdis/149.1.16.
Monobactam antibiotics are a new class of beta-lactam antibiotics. In contrast to penicillins or cephalosporins, monobactams possess a monocyclic beta-lactam structure. IgE or immediate hypersensitivity cross-reactivity between aztreonam (a monobactam) and penicillin was investigated, since this will be an important consideration when therapy is chosen. The maximum concentration of aztreonam reagents not giving false-positive skin tests was determined in normal subjects who were not allergic to penicillin. Subsequently, 41 subjects with IgE antibody to one or more penicillin moieties, as determined by positive skin reactions, were tested with the aztreonam reagents. Thirty-seven of these persons showed no reactivity while four showed equivocal tests. Repeat tests in those four persons were negative to the aztreonam reagents, while their penicillin tests remained unchanged. These in vivo data suggest that there is no cross-reactivity between IgE antibodies to penicillin and aztreonam and provide a basis for investigating the therapeutic use of monobactams in patients who are allergic to penicillin.
单环β-内酰胺类抗生素是一类新型的β-内酰胺抗生素。与青霉素或头孢菌素不同，单环β-内酰胺类具有单环β-内酰胺结构。对氨曲南（一种单环β-内酰胺类抗生素）与青霉素之间的IgE或速发型超敏交叉反应性进行了研究，因为在选择治疗方法时这将是一个重要的考虑因素。在对青霉素不过敏的正常受试者中确定了不会产生假阳性皮肤试验结果的氨曲南试剂的最大浓度。随后，对41名经皮肤反应阳性确定对一种或多种青霉素部分具有IgE抗体的受试者进行了氨曲南试剂检测。其中37人无反应，4人检测结果不明确。对这4人进行的重复检测对氨曲南试剂呈阴性，而他们的青霉素检测结果保持不变。这些体内数据表明，对青霉素的IgE抗体与氨曲南之间不存在交叉反应，并为研究对青霉素过敏患者中单环β-内酰胺类抗生素的治疗用途提供了依据。
