Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Centre for Improving Cancer Outcomes through Enhanced Infection Services, National Health and Medical Research Council Centre of Research Excellence, The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
J Allergy Clin Immunol Pract. 2017 Nov-Dec;5(6):1532-1542. doi: 10.1016/j.jaip.2017.06.017. Epub 2017 Aug 23.
Antibiotic allergy labeling is highly prevalent and negatively impacts patient outcomes and antibiotic appropriateness. Reducing the prevalence and burden of antibiotic allergies requires the engagement of key stakeholders such as allergists, immunologists, pharmacists, and infectious diseases physicians. To help address this burden of antibiotic allergy overlabeling, we review 3 key antibiotic allergy domains: (1) antibiotic allergy classification, (2) antibiotic cross-reactivity, and (3) multidisciplinary collaboration. We review the available evidence and research gaps of currently used adverse drug reaction classification systems, antibiotic allergy cross-reactivity, and current and future models of antibiotic allergy care.
抗生素过敏标签非常普遍，会对患者的预后和抗生素的合理使用产生负面影响。减少抗生素过敏的发生率和负担需要过敏症专家、免疫学家、药剂师和传染病医生等关键利益相关者的参与。为了帮助解决抗生素过敏过度标签的负担，我们回顾了 3 个关键的抗生素过敏领域：（1）抗生素过敏分类，（2）抗生素交叉反应，和（3）多学科合作。我们回顾了现有的证据和研究差距，包括当前使用的药物不良反应分类系统、抗生素过敏交叉反应，以及当前和未来的抗生素过敏护理模式。
