Holl G, Hahn H
Arzneimittelforschung. 1984;34(1):39-43.
The influence of Cefaclor and of Tobramycin on phagocytosis of sheep erythrocytes by murine peritoneal macrophages was investigated. The antibiotics in various concentrations were either added to the cells directly during the phagocytosis period or injected i.v. into cell donor mice at different times before cell harvest and the cells subsequently assayed for phagocytic activity in vitro. When antibiotic was added during the phagocytosis a dose-dependent inhibition of phagocytosis was observed which, however, became significant only at extremely high concentrations of the antibiotic. In all other experimental set-ups, phagocytosis was not influenced by antibiotics. Restrictive usage of either antibiotic in clinical situation does not appear mandatory on the basis of the reported observations.
研究了头孢克洛和妥布霉素对小鼠腹腔巨噬细胞吞噬绵羊红细胞的影响。将不同浓度的抗生素在吞噬期直接加入细胞中，或在收获细胞前的不同时间静脉注射到细胞供体小鼠体内，随后检测细胞的体外吞噬活性。当在吞噬过程中加入抗生素时，观察到吞噬作用呈剂量依赖性抑制，但只有在抗生素浓度极高时才具有显著意义。在所有其他实验设置中，吞噬作用不受抗生素影响。根据所报道的观察结果，在临床情况下，这两种抗生素的限制性使用似乎并非必需。
