Pfåndner K
Arzneimittelforschung. 1984;34(1):77-9.
A double-blind parallel 20-day trial was carried out in 40 patients with acute infectious inflammation of the urogenital tract to compare the effectiveness of antibiotic treatments alone or with concomitant use of a new non-steroidal antiinflammatory drug, 4-nitro-2-phenoxymethane sulfonanilide (nimesulide) 200 mg/d. During the course of the treatment, nimesulide plus antibiotics induced a significantly greater and more rapid improvement of the treated patients in comparison with antibiotics plus placebo, in case of prostate swelling, redness, oedema, compulsion, pollakiuria, nycturia and body temperature. The assessment on efficacy expressed by the investigator and the patient was significantly better in the case of antibiotic plus nimesulide as compared to the antibiotic treatment alone (p less than 0.01). With the improvement of clinical complaints, there resulted a significant reduction of erythrocyte sedimentation rate and of white blood cell count. In the antibiotic plus nimesulide treatment group, the laboratory parameters used as a control for the tolerability of the drug did not show any significant variation. There were no side-effects reported.
对40例急性泌尿生殖道感染性炎症患者进行了一项为期20天的双盲平行试验，以比较单独使用抗生素或同时使用一种新型非甾体抗炎药（4-硝基-2-苯氧甲基磺酰苯胺，即尼美舒利，200毫克/天）的治疗效果。在治疗过程中，与抗生素加安慰剂相比，在前列腺肿胀、发红、水肿、紧迫感、尿频、夜尿和体温方面，尼美舒利加抗生素使治疗患者的改善更为显著且迅速。研究者和患者对疗效的评估显示，抗生素加尼美舒利的情况明显优于单独使用抗生素治疗（p小于0.01）。随着临床症状的改善，红细胞沉降率和白细胞计数显著降低。在抗生素加尼美舒利治疗组中，用作药物耐受性对照的实验室参数未显示任何显著变化。未报告有副作用。
