牛颈动脉培养内皮细胞中植物甾醇刺激纤溶酶原激活物的产生。

Sitosterol-stimulative production of plasminogen activator in cultured endothelial cells from bovine carotid artery.

作者信息

Hagiwara H, Shimonaka M, Morisaki M, Ikekawa N, Inada Y

出版信息

Thromb Res. 1984 Feb 15;33(4):363-70. doi: 10.1016/0049-3848(84)90075-6.

Abstract

The endothelial cell is a rich source of plasminogen activator that is associated with fibrinolytic activity in blood vessel. Addition of sitosterol to the culture medium of endothelial cells from bovine carotid artery gave rise to a marked increment in the activity of plasminogen activator. Removal of sitosterol from the culture medium resulted in a decrease of plasminogen activator activity back to normal levels. Enhancement of plasminogen activator activity in cultured endothelial cells was not observed by cholesterol, 5-androsten-3 beta-ol and others.

摘要

内皮细胞是纤溶酶原激活剂的丰富来源，与血管中的纤维蛋白溶解活性相关。向牛颈动脉内皮细胞的培养基中添加谷甾醇会导致纤溶酶原激活剂的活性显著增加。从培养基中去除谷甾醇会导致纤溶酶原激活剂活性降至正常水平。胆固醇、5-雄甾-3β-醇等未观察到对培养的内皮细胞中纤溶酶原激活剂活性的增强作用。