噻苯达唑与非班太尔对大鼠实验性旋毛虫病疗效的比较。

A comparison between the efficacy of thiabendazole and febantel on experimental trichinellosis in rats.

作者信息

Alcaíno H A, Gorman T R, Elorrieta M B

出版信息

Vet Parasitol. 1984 Mar;14(2):153-7. doi: 10.1016/0304-4017(84)90121-3.

Abstract

Febantel at a dose level of 5 mg kg-1 had a lethal efficacy of 54.1% against the adult worm and 69.5% against the migrating larvae of Trichinella spiralis in rats. When administered at 15 mg kg-1, it demonstrated lethal effects of 94.4, 92.5 and 74.7% against adult, young and encysted larvae, respectively. Infected rats treated with 300 mg kg-1 died. Thiabendazole had efficiencies of 96.4 and 83.3% against intestinal and migrating early muscle phases, respectively, and was 42% effective against the encysting phase.

摘要

非班太尔剂量为5毫克/千克时，对大鼠旋毛虫成虫的致死效力为54.1%，对移行幼虫的致死效力为69.5%。以15毫克/千克给药时，其对成虫、幼虫和包囊幼虫的致死率分别为94.4%、92.5%和74.7%。用300毫克/千克治疗的感染大鼠死亡。噻苯达唑对肠道期和移行早期肌肉期的效率分别为96.4%和83.3%，对包囊期的有效性为42%。