Soliman Gamal A, Taher Eman S, Mahmoud Maha A
Research Institute of Ophthalmology, Clinical Parasitology, Cairo, Egypt.
Turkiye Parazitol Derg. 2011;35(2):86-91. doi: 10.5152/tpd.2011.22.
Three commonly used antihelmenthic drugs including Dormectin (0.2 mg/kg), Ivermectin (0.2 mg/kg) and Levamisole (7.5 mg/kg) were examined for their antihelmenthic efficacy against experimental Trichinella spiralis infection in rats.
One hundred and twenty rats were orally infected with 500 T. spiralis larvae. Drugs were tested against adult worms at 4th day, against migrating larvae at 10th days and against encysted larvae at 35th day post infection (dpi). Rats were sacrificed five days post treatment. Mature worms and migrating larvae counts were detected.
Significant effect was detected in rats treated with Dormectin and Ivermectin compared to non-treated controls. Dormectin showed an efficacy of 97.75% and 86.23% in eliminating both mature worms and migrating larvae respectively. Ivermectin showed an efficacy of 94.99% and 83.85% respectively. However, Levamisole was the least effective drug; its efficacy was 4.83% and 3.57% against mature worms and migrating larvae respectively.
All of the tested drugs failed to inhibit the encysted larvae in the diaphragms. Moreover, T. spiralis infection in rats reduced significantly the values of total proteins, and albumin while globulin, urea and creatinine values were significantly increased together with AST and ALT activities.
研究三种常用抗蠕虫药物——多拉菌素（0.2毫克/千克）、伊维菌素（0.2毫克/千克）和左旋咪唑（7.5毫克/千克）对大鼠实验性旋毛虫感染的抗蠕虫效果。
120只大鼠经口感染500条旋毛虫幼虫。在感染后第4天对成虫进行药物测试，第10天对移行幼虫进行测试，第35天对包囊幼虫进行测试。治疗后5天处死大鼠，检测成熟虫体和移行幼虫数量。
与未治疗的对照组相比，多拉菌素和伊维菌素治疗的大鼠有显著效果。多拉菌素清除成熟虫体和移行幼虫的效果分别为97.75%和86.23%。伊维菌素的效果分别为94.99%和83.85%。然而，左旋咪唑是效果最差的药物；其对成熟虫体和移行幼虫的效果分别为4.83%和3.57%。
所有测试药物均未能抑制膈肌中的包囊幼虫。此外，大鼠的旋毛虫感染显著降低了总蛋白和白蛋白的值，而球蛋白、尿素和肌酐值以及谷草转氨酶和谷丙转氨酶活性显著升高。
