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1
In vitro antimicrobial activity of aztreonam alone and in combination against bacterial isolates from pediatric patients.氨曲南单独及联合使用对儿科患者分离菌株的体外抗菌活性。
Antimicrob Agents Chemother. 1984 Feb;25(2):212-5. doi: 10.1128/AAC.25.2.212.
2
In vitro activity of carumonam.卡芦莫南的体外活性。
Antimicrob Agents Chemother. 1985 Dec;28(6):834-6. doi: 10.1128/AAC.28.6.834.
3
Aminoglycosides plus beta-lactams against gram-negative organisms. Evaluation of in vitro synergy and chemical interactions.氨基糖苷类药物与β-内酰胺类药物联合用于抗革兰氏阴性菌。体外协同作用及化学相互作用的评估。
Am J Med. 1986 Jun 30;80(6B):126-37. doi: 10.1016/0002-9343(86)90490-0.
4
N-formimidoyl thienamycin: in vitro comparison with cefoxitin and tobramycin against clinical, bacterial isolates.N-甲酰亚胺基硫霉素：与头孢西丁和妥布霉素对临床分离细菌的体外比较
Acta Pathol Microbiol Immunol Scand B. 1983 Apr;91(2):141-4. doi: 10.1111/j.1699-0463.1983.tb00023.x.
5
In vitro activity of aztreonam in combination with newer beta-lactams and amikacin against multiply resistant gram-negative bacilli.氨曲南与新型β-内酰胺类抗生素及阿米卡星联合应用对多重耐药革兰阴性杆菌的体外活性
Antimicrob Agents Chemother. 1984 Feb;25(2):283-5. doi: 10.1128/AAC.25.2.283.
6
Effect of aztreonam in combination with azlocillin or piperacillin on Pseudomonas aeruginosa.氨曲南联合阿洛西林或哌拉西林对铜绿假单胞菌的作用
Antimicrob Agents Chemother. 1984 Oct;26(4):519-21. doi: 10.1128/AAC.26.4.519.
7
In vitro activities of antibiotic combinations against clincal isolates of Pseudomonas aeruginosa.抗生素组合对铜绿假单胞菌临床分离株的体外活性
Kaohsiung J Med Sci. 2004 Jun;20(6):261-7. doi: 10.1016/s1607-551x(09)70116-0.
8
In vitro antimicrobial activity of piperacillin/tazobactam in comparison with other broad-spectrum beta-lactams.哌拉西林/他唑巴坦与其他广谱β-内酰胺类药物相比的体外抗菌活性。
Braz J Infect Dis. 2000 Oct;4(5):226-35.
9
In vitro activity of aztreonam against gram negative bacteria from clinical specimens and its comparison with other commonly used antibiotics.氨曲南对临床标本中革兰阴性菌的体外活性及其与其他常用抗生素的比较。
Methods Find Exp Clin Pharmacol. 1986 Apr;8(4):223-6.
10
Antibacterial activity of tobramycin against gram-negative bacteria and the combination of ampicillin/tobramycin against E. coli.妥布霉素对革兰氏阴性菌的抗菌活性以及氨苄西林/妥布霉素联合用药对大肠杆菌的抗菌活性。
Chemotherapy. 1975;21(2):90-8. doi: 10.1159/000221851.

引用本文的文献

1
Infectious disease: how to manage Gram-positive and Gram-negative pathogen conundrums with dual beta-lactam therapy.传染病：如何通过双β-内酰胺疗法应对革兰氏阳性菌和革兰氏阴性菌病原体难题。
Drugs Context. 2022 Jan 20;11. doi: 10.7573/dic.2021-8-9. eCollection 2022.
2
Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.协同、侧支敏感的β-内酰胺类联合用药可抑制耐甲氧西林金黄色葡萄球菌（MRSA）的耐药性。
Nat Chem Biol. 2015 Nov;11(11):855-61. doi: 10.1038/nchembio.1911. Epub 2015 Sep 14.
3
Evaluation of aztreonam in the treatment of severe bacterial infections.氨曲南治疗严重细菌感染的评估。
Antimicrob Agents Chemother. 1985 Aug;28(2):222-6. doi: 10.1128/AAC.28.2.222.
4
Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.氨曲南。对其抗菌活性、药代动力学特性及治疗用途的综述。
Drugs. 1986 Feb;31(2):96-130. doi: 10.2165/00003495-198631020-00002.
5
[A comparative review of combination therapy: 2 beta-lactams versus beta-lactam plus aminoglycoside].联合治疗的比较综述：两种β-内酰胺类药物与β-内酰胺类药物加氨基糖苷类药物的对比
Infection. 1987;15 Suppl 4:S158-67. doi: 10.1007/BF01645863.

本文引用的文献

1
Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.核酸衍生物拮抗剂。VIII. 生物化学相关抗代谢物组合中的协同作用。
J Biol Chem. 1954 Jun;208(2):477-88.
2
Pharmacokinetics of the monobactam SQ 26,776 after single intravenous doses in healthy subjects.
J Antimicrob Chemother. 1981 Dec;8 Suppl E:131-40. doi: 10.1093/jac/8.suppl_e.131.
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The assessment of antimicrobial combinations.抗菌药物联合使用的评估
Rev Infect Dis. 1981 May-Jun;3(3):627-33. doi: 10.1093/clinids/3.3.627.
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Monocyclic beta-lactam antibiotics produced by bacteria.细菌产生的单环β-内酰胺抗生素。
Nature. 1981 Jun 11;291(5815):489-91. doi: 10.1038/291489a0.
5
Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.氨曲南（SQ 26,776），一种对需氧革兰氏阴性菌有特效的合成单环β-内酰胺抗生素。
Antimicrob Agents Chemother. 1982 Jan;21(1):85-92. doi: 10.1128/AAC.21.1.85.
6
Comparative in vitro study of SQ26,776.SQ26,776的体外对比研究。
Antimicrob Agents Chemother. 1982 Feb;21(2):294-8. doi: 10.1128/AAC.21.2.294.
7
In vitro activity of azthreonam, a monobactam antibiotic.单环β-内酰胺类抗生素氨曲南的体外活性
Antimicrob Agents Chemother. 1982 Nov;22(5):832-8. doi: 10.1128/AAC.22.5.832.
8
In vitro activity of cefoxitin, alone and in combination with aminoglycoside or other beta-lactam antibiotics against common gram-negative pathogens.
Chemotherapy. 1983;29(2):89-98. doi: 10.1159/000238180.
9
Antibacterial activity of the monobactam SQ 26,776 against antibiotic resistant enterobacteria, including Serratia spp.
J Antimicrob Chemother. 1981 Dec;8 Suppl E:57-68. doi: 10.1093/jac/8.suppl_e.57.
10
Novel resistance selected by the new expanded-spectrum cephalosporins: a concern.新型广谱头孢菌素所选择的新型耐药性：一个值得关注的问题。
J Infect Dis. 1983 Mar;147(3):585-9. doi: 10.1093/infdis/147.3.585.

氨曲南单独及联合使用对儿科患者分离菌株的体外抗菌活性。

In vitro antimicrobial activity of aztreonam alone and in combination against bacterial isolates from pediatric patients.

作者信息

Stutman H R, Welch D F, Scribner R K, Marks M I

出版信息

Antimicrob Agents Chemother. 1984 Feb;25(2):212-5. doi: 10.1128/AAC.25.2.212.

DOI:10.1128/AAC.25.2.212
PMID:6538772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185476/
Abstract

We examined 134 pediatric clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa, and gram-positive cocci for susceptibility to aztreonam alone and in combination with seven other antibiotics. All 98 gram-negative isolates were susceptible to aztreonam with similar inhibitory and bactericidal activity. Combinations of aztreonam with cefoxitin, ampicillin, or clindamycin were generally indifferent or additive. Synergism was occasionally seen against enteric organisms with aztreonam plus cefoxitin or clindamycin. Combinations of tobramycin and aztreonam were synergistic (62%) against P. aeruginosa; aztreonam plus piperacillin or ticarcillin was additive. Aztreonam did not affect the activity of nafcillin against Staphylococcus aureus, or of ampicillin against species of Streptococcus group B or D. Antagonism was seen only with aztreonam plus cefoxitin against Enterobacter species, but not at clinically significant concentrations. Several combinations of antibiotics with aztreonam should be appropriate for initial therapy of infections in children without major risks of antibacterial antagonism.

摘要

我们检测了134株儿科临床分离的肠杆菌科细菌、铜绿假单胞菌和革兰氏阳性球菌对氨曲南单独使用以及与其他七种抗生素联合使用时的敏感性。所有98株革兰氏阴性菌分离株对氨曲南敏感，且具有相似的抑菌和杀菌活性。氨曲南与头孢西丁、氨苄西林或克林霉素联合使用时通常表现为无关或相加作用。氨曲南加头孢西丁或克林霉素偶尔对肠道菌有协同作用。妥布霉素与氨曲南联合使用对铜绿假单胞菌有协同作用（62%）；氨曲南加哌拉西林或替卡西林为相加作用。氨曲南不影响萘夫西林对金黄色葡萄球菌的活性，也不影响氨苄西林对B组或D组链球菌的活性。仅在氨曲南加头孢西丁对肠杆菌属细菌时观察到拮抗作用，但在临床有效浓度时未观察到。几种氨曲南与抗生素的联合用药应适用于无明显抗菌拮抗风险的儿童感染的初始治疗。