Akazawa S, Kitagawa H, Nakagawa T, Fujiki T, Kanda Y, Futatsuki K, Sampi K, Fujita K
Gan To Kagaku Ryoho. 1984 May;11(5):1018-23.
Eleven patients with advanced squamous cell carcinoma of the esophagus were treated with a two-drug combination of cis-diammine dichloroplatinum and vindesine sulfate at Saitama Cancer Center between July 1982 and September 1983. Median age was 71 years old (range: 47-48) and 8 patients were greater than 70 years old. Median performance status was 3 (range: 1-4) by Koyama -Saito Criteria. Male female ratio was 6:5. Of the 11 patents, three obtained partial response (27.3%), lasting 8 weeks, 20 weeks+, and 42 weeks-, respectively, and three patients had minor response (27.3%). The major toxic effects including myelosuppression, nausea and vomiting were in general manageable.
1982年7月至1983年9月间，埼玉癌症中心对11例晚期食管鳞状细胞癌患者采用顺二氯二氨铂和硫酸长春地辛两药联合方案进行治疗。中位年龄为71岁（范围：47 - 88岁），8例患者年龄大于70岁。根据小山-斋藤标准，中位体能状态为3（范围：1 - 4）。男女比例为6:5。11例患者中，3例获得部分缓解（27.3%），缓解持续时间分别为8周、20周以上和42周以下，3例患者有轻微缓解（27.3%）。包括骨髓抑制、恶心和呕吐在内的主要毒性作用总体上是可控的。
