Tönjes R, Kitzrow W, Poppe I, Dörner G
Exp Clin Endocrinol. 1984 Mar;83(1):1-5. doi: 10.1055/s-0029-1210305.
The effect of pargyline on 5 HT concentration in a combined forebrain and midbrain section ( FMB ) have been investigated in female rats which were temporarily deprived from their dams in postnatal life and daily injected with the monoamine oxidase inhibitor. Two hours after the last pargyline injection a marked increase in 5 HT concentration could be observed both in 12 and 30 days-old rats. The question is raised whether 5 HT may be involved in neuroendocrine mechanisms which are responsible for controlling the onset of puberty, since a significant advance of puberty could be achieved by this pargyline treatment in normal and deprived female rats.
已对产后暂时与母鼠分离并每日注射单胺氧化酶抑制剂的雌性大鼠，研究了优降宁对联合前脑和中脑切片（FMB）中5-羟色胺浓度的影响。在最后一次注射优降宁两小时后，可观察到12日龄和30日龄大鼠的5-羟色胺浓度均显著升高。由于这种优降宁处理可使正常和被剥夺母鼠的青春期显著提前，因此提出了5-羟色胺是否可能参与负责控制青春期开始的神经内分泌机制的问题。
