Gipps E M, Kidson C
Neurology. 1984 Jun;34(6):808-11. doi: 10.1212/wnl.34.6.808.
As a group, of 40 MS patients exhibited significantly more cellular sensitivity to ionizing (gamma) radiation than 30 age- and sex-matched controls (p less than 0.0001), as measured by radiation-induced chromosome aberrations. Studies of phytohemagglutinin-stimulated T lymphocytes, B lymphoblastoid cell lines, and fibroblasts indicated that the cellular radiosensitivity was a general property of the cells of an individual. Patterns of cellular radiosensitivity among the unaffected first-degree relatives of some MS patients suggested autosomal dominant inheritance. Cellular radiosensitivity may be due to mutations of DNA-processing that predispose to MS.
作为一个群体，40名多发性硬化症患者对电离（γ）辐射表现出比30名年龄和性别匹配的对照者显著更高的细胞敏感性（p小于0.0001），这是通过辐射诱导的染色体畸变来测量的。对植物血凝素刺激的T淋巴细胞、B淋巴母细胞系和成纤维细胞的研究表明，细胞放射敏感性是个体细胞的一种普遍特性。一些多发性硬化症患者未受影响的一级亲属中的细胞放射敏感性模式提示常染色体显性遗传。细胞放射敏感性可能是由于DNA加工的突变导致易患多发性硬化症。
