Heilmann L, Siekmann U
Arzneimittelforschung. 1984;34(3):298-302.
In the present article the interaction of 1- isopropylamino-3-[4-(2-methoxyethyl)-phenoxy]-2-propanol (metoprolol, Beloc) with human erythrocytes is reported. Metoprolol is well known and acts mainly as a selective beta-1-antagonist. While erythrocyte aggregation, suspension osmolality and pH-values were unchanged, red cell deformability was markedly improved. Investigation into the furosemide-sensitive fluxes resulted in an inhibition of sodium efflux and in a constant water content of human erythrocytes. These in vitro results suggest that metoprolol induced improvement of red cell deformability cannot be explained by shape changes of erythrocytes.
本文报道了1-异丙氨基-3-[4-(2-甲氧基乙基)-苯氧基]-2-丙醇（美托洛尔，倍他乐克）与人红细胞的相互作用。美托洛尔广为人知，主要作为一种选择性β-1拮抗剂发挥作用。虽然红细胞聚集、悬浮渗透压和pH值未发生变化，但红细胞变形性显著改善。对速尿敏感通量的研究导致钠外流受到抑制，且人红细胞的含水量保持恒定。这些体外实验结果表明，美托洛尔引起的红细胞变形性改善无法用红细胞形状变化来解释。
