Gutcher G R, Lax A A, Farrell P M
JPEN J Parenter Enteral Nutr. 1984 May-Jun;8(3):269-73. doi: 10.1177/0148607184008003269.
Conflicting reports exist regarding the relative tocopherol isomer content of Intralipid ranging from 99% as alpha-tocopherol to as much as 90% as gamma-tocopherol. Our direct assay of Intralipid as well as plasma levels measured in premature infants receiving Intralipid confirm the existence of a low alpha, high gamma-tocopherol content and imply the need for alpha-tocopherol supplementation in patients receiving Intralipid, particularly the relatively tocopherol-deficient premature infant. Furthermore, the observation of abnormal erythrocyte hemolysis test values despite "normal" total tocopherol plasma concentrations may be explained by high plasma levels of non-alpha, biologically less active isomers. The quantitation of tocopherol isomers helps explain this discrepancy and suggests the need for future studies of vitamin E status to employ measurements of tocopherol isomers in reporting results.
关于英脱利匹特中生育酚异构体的相对含量存在相互矛盾的报道，其范围从99%为α-生育酚到高达90%为γ-生育酚。我们对英脱利匹特的直接测定以及对接受英脱利匹特的早产儿血浆水平的测定证实，存在低α、高γ-生育酚含量的情况，这意味着接受英脱利匹特的患者，尤其是相对缺乏生育酚的早产儿，需要补充α-生育酚。此外，尽管总生育酚血浆浓度“正常”，但红细胞溶血试验值异常这一观察结果，可能是由于非α、生物活性较低的异构体血浆水平较高所致。生育酚异构体的定量有助于解释这种差异，并表明未来关于维生素E状态的研究在报告结果时需要采用生育酚异构体的测量方法。
