Vandewoude M G, Vandewoude M F, De Leeuw I H
JPEN J Parenter Enteral Nutr. 1986 May-Jun;10(3):303-5. doi: 10.1177/0148607186010003303.
Low vitamin E levels have been found to be a frequent side effect in patients on total parenteral nutrition (TPN). In the present study, the vitamin E content of fat emulsions (Intralipid) was measured and the influence of the intravenously administered lipid emulsion on plasma vitamin E levels was investigated. The majority of vitamin E was provided in the beta + gamma-tocopherol fractions (68.7% of total tocopherol). Vitamin E levels in patients were significantly lower (p less than 0.05) as compared to age- and sex-matched normal controls. Although sufficient amounts of vitamin E (16.9 +/- 0.8 IU daily) were infused, according to RDA requirements, E-plasma levels decreased even further during the course of TPN. It was concluded that high amounts of biologically less active tocopherol isomers are not sufficient to maintain vitamin E plasma levels. Supplemental sources of alpha-tocopherol are needed and more attention should be paid to the different tocopherol isomers in the quantitation of the daily allowances of vitamin E.
已发现维生素E水平低是接受全胃肠外营养（TPN）患者常见的副作用。在本研究中，测定了脂肪乳剂（英脱利匹特）中的维生素E含量，并研究了静脉输注脂肪乳剂对血浆维生素E水平的影响。大部分维生素E存在于β+γ-生育酚组分中（占总生育酚的68.7%）。与年龄和性别匹配的正常对照组相比，患者的维生素E水平显著降低（p<0.05）。尽管根据推荐膳食摄入量（RDA）要求输注了足量的维生素E（每日16.9±0.8国际单位），但在TPN过程中，血浆E水平仍进一步下降。得出的结论是，大量生物活性较低的生育酚异构体不足以维持血浆维生素E水平。需要补充α-生育酚来源，并且在定量维生素E每日摄入量时应更加关注不同的生育酚异构体。
