Boehme R E, Baker T L, Mefford I N, Barchas J D, Dement W C, Ciaranello R D
Life Sci. 1984 May 7;34(19):1825-8. doi: 10.1016/0024-3205(84)90675-1.
An inbred colony of narcoleptic doberman pinschers has been analyzed for muscarinic receptor levels in 19 discrete brain regions. In comparison to age-matched controls, receptors were generally elevated in the brainstem and reduced in forebrain areas. No changes in receptor binding affinity were detected. The increased receptor levels found in the brainstem suggest that cholinoceptive neurons in this region are hypersensitive and may be involved in the initiation of cataplexy and other aspects of the narcolepsy syndrome.
对一个患有发作性睡病的杜宾犬近交系群体的19个离散脑区的毒蕈碱受体水平进行了分析。与年龄匹配的对照组相比，脑干中的受体普遍升高，而前脑区域的受体则减少。未检测到受体结合亲和力的变化。在脑干中发现的受体水平升高表明，该区域的胆碱能感受神经元高度敏感，可能参与猝倒发作及发作性睡病综合征的其他方面。
