Baroni A, Benvenuti F, Fantini L, Pantaleo T, Urbani F
Neurology. 1984 Jul;34(7):868-76. doi: 10.1212/wnl.34.7.868.
In patients with Parkinson's disease who had never previously been treated with any antiparkinsonism drug, we studied the effects of L-dopa on ballistic arm abduction movement in a step-tracking task. L-Dopa treatment increased the mean velocity of the initial movement towards the target without loss of accuracy and with improved motor performance under open-loop conditions. Performance also improved in motor tasks with expected perturbation. EMG patterns of arm abduction movements showed abnormal features in untreated patients and improved after L-dopa treatment.
在从未接受过任何抗帕金森病药物治疗的帕金森病患者中，我们研究了左旋多巴对步进跟踪任务中手臂弹道式外展运动的影响。左旋多巴治疗增加了向目标初始运动的平均速度，在开环条件下没有损失准确性且运动表现得到改善。在有预期干扰的运动任务中表现也有所改善。手臂外展运动的肌电图模式在未治疗的患者中显示出异常特征，在左旋多巴治疗后得到改善。
