Weinrich M, Koch K, Garcia F, Angel R W
Department of Neurology, Palo Alto VA Medical Center, CA 94304.
Neurology. 1988 Apr;38(4):540-5. doi: 10.1212/wnl.38.4.540.
We measured axial (head rotation) and distal (wrist flexion and extension) movements in parkinsonian patients with varying stages of disability, before and after administration of L-dopa. Velocities for both movements were proportionately reduced in all stages of disease. L-Dopa administration provided a small but consistent increase in distal movement velocity for most patients, whereas in patients with advanced disease (stages III to V), axial movement velocity actually declined after administration of L-dopa. This decline may be partially responsible for the failure of L-dopa administration to reverse the loss of "righting reflexes" in these patients. Measurement of axial motor control may be a useful tool in evaluating therapeutics for Parkinson's disease patients.
我们测量了处于不同残疾阶段的帕金森病患者在服用左旋多巴前后的轴向运动（头部转动）和远端运动（手腕屈伸）。在疾病的所有阶段，这两种运动的速度均成比例降低。对大多数患者而言，服用左旋多巴使远端运动速度有小幅但持续的提高，而在晚期疾病患者（III至V期）中，服用左旋多巴后轴向运动速度实际上下降了。这种下降可能部分导致了左旋多巴给药未能逆转这些患者“翻正反射”丧失的情况。测量轴向运动控制可能是评估帕金森病患者治疗方法的有用工具。
