Polinsky R J, Jimerson D C, Kopin I J
Neurology. 1984 Jul;34(7):979-83. doi: 10.1212/wnl.34.7.979.
We measured CSF and plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) in patients with orthostatic hypotension. Total CSF MHPG levels were significantly lower than normal in patients with either multiple system atrophy (MSA) or idiopathic orthostatic hypotension (IOH). Only IOH patients had low plasma levels of MHPG. Correction of CSF MHPG levels for the contribution from plasma free MHPG provides an index of central norepinephrine metabolism. In MSA, abnormal function of central noradrenergic pathways seems to cause the low CSF MHPG levels. In IOH, the decreased CSF MHPG results from the diminished plasma MHPG levels.
我们测量了体位性低血压患者脑脊液和血浆中3-甲氧基-4-羟基苯乙二醇（MHPG）的水平。多系统萎缩（MSA）或特发性体位性低血压（IOH）患者的脑脊液总MHPG水平显著低于正常水平。只有IOH患者的血浆MHPG水平较低。校正脑脊液MHPG水平中来自血浆游离MHPG的贡献可提供中枢去甲肾上腺素代谢的指标。在MSA中，中枢去甲肾上腺素能通路的异常功能似乎导致脑脊液MHPG水平降低。在IOH中，脑脊液MHPG水平降低是由于血浆MHPG水平降低所致。
