Piver M S, Barlow J J, Lele S B, Maniccia M
Gynecol Oncol. 1984 Jul;18(3):313-9. doi: 10.1016/0090-8258(84)90042-8.
Twenty-four evaluable patients with recurrent carcinoma of the cervix after previous pelvic irradiation were treated with cis-diamminedichloroplatinum II (cis-DDP). Of the 14 patients who received low-dose (1 mg/kg) weekly induction cis-DDP, 10 (71%) responded, 6 (43%) of which were complete responses. Four (40%) of the ten patients who received high-dose (100 mg/m2) monthly cis-DDP responded, two of which were complete responses. Maintenance of these responses by combination chemotherapy which includes cis-DDP remains a significant problem.
24例先前盆腔放疗后复发的宫颈癌可评估患者接受了顺二氯二氨铂（cis-DDP）治疗。在14例接受低剂量（1mg/kg）每周诱导顺铂治疗的患者中，10例（71%）有反应，其中6例（43%）为完全缓解。在10例接受高剂量（100mg/m²）每月顺铂治疗的患者中，4例（40%）有反应，其中2例为完全缓解。通过包括顺铂在内的联合化疗维持这些反应仍然是一个重大问题。
