Alpert B S, Jureidini S B, Vanderzalm T
South Med J. 1984 Aug;77(8):1039-40. doi: 10.1097/00007611-198408000-00027.
Prostaglandin E1 (PGE1) has been used to preserve patency of the ductus arteriosus in various forms of congenital heart disease. Long-term PGE1 therapy often leads to the roentgenographic findings of cortical hyperostosis, similar to those seen in infectious or metabolic diseases. These periosteal reactions regress after cessation of PGE1 therapy and should not prompt further diagnostic evaluation.
前列腺素E1（PGE1）已被用于维持各种先天性心脏病中动脉导管的通畅。长期使用PGE1治疗常导致X线表现为皮质骨增生，类似于在感染性或代谢性疾病中所见。这些骨膜反应在停止PGE1治疗后会消退，不应促使进一步的诊断评估。
