T-2毒素、HT-2毒素、二乙酰氧基雪腐镰刀菌烯醇和脱氧雪腐镰刀菌烯醇对牛血小板功能的抑制作用

Inhibition of bovine platelet function by T-2 toxin, HT-2 toxin, diacetoxyscirpenol and deoxynivalenol.

作者信息

Chan P K, Gentry P A

出版信息

Food Chem Toxicol. 1984 Aug;22(8):643-8. doi: 10.1016/0278-6915(84)90273-4.

Abstract

The aggregation of bovine platelets suspended in homologous plasma is inhibited in the presence of T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) or deoxynivalenol (DON) when either collagen or ADP is used as the stimulatory agent for aggregation. For each of the mycotoxins the degree of inhibition is dependent on the amount of trichothecene present in the platelet suspension but is not dependent on the time of exposure of the platelets to the toxin. For both ADP- and collagen-stimulated platelets, the order of potency of inhibition is T-2 toxin greater than HT-2 toxin greater than DAS greater than DON. A significant (P less than 0.01) dose-dependent decrease was also observed in the amount of the thromboxane B2 released from collagen-stimulated platelets in the presence of each of the mycotoxins.

摘要

当以胶原蛋白或二磷酸腺苷（ADP）作为聚集刺激剂时，悬浮于同源血浆中的牛血小板聚集在T-2毒素、HT-2毒素、二乙酰氧基镰刀菌烯醇（DAS）或脱氧雪腐镰刀菌烯醇（DON）存在的情况下受到抑制。对于每种霉菌毒素，抑制程度取决于血小板悬液中存在的单端孢霉烯的量，但不取决于血小板与毒素接触的时间。对于ADP和胶原蛋白刺激的血小板，抑制效力顺序为T-2毒素＞HT-2毒素＞DAS＞DON。在每种霉菌毒素存在的情况下，从胶原蛋白刺激的血小板释放的血栓素B2的量也观察到显著（P＜0.01）的剂量依赖性降低。