da Silva V, Gutin P H, Barcellos-Hoff M H, Bernstein M A, Deen D F, Weaver K A
Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1471-2. doi: 10.1016/0360-3016(84)90370-5.
We studied the effect of combination treatment with cis-platinum during low dose rate irradiation from 125I sources in the RIF-1 murine flank tumor model. Cell survival measured with a colony forming efficiency assay was used as the experimental endpoint. Sources implanted into tumors delivered 25 Gy of radiation to isodosed annuli of tissue at a dose rate of 1.3 Gy/hr. When 3 mg/kg of cis-platinum was administered 24, 12, and 1 hr before or 0, 12 and 24 hr after irradiation, the effect on cell kill was additive. Thus in the RIF-1 model there is no particular advantage gained by treatment with the combinations of cis-platinum and 125I radiation used in these studies.
我们在RIF-1小鼠胁腹肿瘤模型中研究了在低剂量率125I源照射期间联合顺铂治疗的效果。采用集落形成效率试验测量细胞存活率作为实验终点。植入肿瘤的放射源以1.3 Gy/小时的剂量率向等剂量组织环输送25 Gy的辐射。当在照射前24、12和1小时或照射后0、12和24小时给予3 mg/kg顺铂时，对细胞杀伤的作用是相加的。因此，在RIF-1模型中，使用本研究中的顺铂和125I辐射联合治疗并没有特别的优势。
