Da Silva V F, Gutin P H, Deen D F, Weaver K A
Int J Radiat Oncol Biol Phys. 1984 Nov;10(11):2109-11. doi: 10.1016/0360-3016(84)90209-8.
The relative biological effectiveness of 125I and 192Ir has been determined in a murine brachytherapy model that uses a clonogenic cell assay as the end point. Removable 125I or 192Ir sources were implanted at right angles to the surface of RIF-1 tumors grown in the flanks of C3H/He mice. After irradiation for 1-5 days, mice were sacrificed and isodosed annuli of irradiated tumor tissue were sampled for the clonogenic cell assay. The slopes and intercepts of the two radiation survival curves for implanted sources with activities of 10 to 50 Gy for 125I (dose rate = 39.8 +/- 4.3 cGy/hr) and 192Ir (dose rate = 42.3 +/- 2.7 cGy/hr) were identical; the relative biological effectiveness was 1.
在一个以克隆形成细胞试验作为终点的小鼠近距离放射治疗模型中，已测定了¹²⁵I和¹⁹²Ir的相对生物效能。将可移除的¹²⁵I或¹⁹²Ir源与生长在C3H/He小鼠胁腹的RIF-1肿瘤表面成直角植入。照射1至5天后，处死小鼠，对受照射肿瘤组织的等剂量环进行取样，用于克隆形成细胞试验。对于¹²⁵I（剂量率 = 39.8 ± 4.3 cGy/小时）和¹⁹²Ir（剂量率 = 42.3 ± 2.7 cGy/小时），活性为10至50 Gy的植入源的两条辐射存活曲线的斜率和截距相同；相对生物效能为1。
