Inouye E, Park K S, Asaka A
Acta Genet Med Gemellol (Roma). 1984;33(2):237-42. doi: 10.1017/s0001566000007273.
Applying newly devised model, heritability (VA/VP) of plasma uric acid level, corrected for age and sex and standardized, was estimated at 0.8 in families consisting of twin parents, spouses and children. Correlation between spouses due to common genotype (rho) was approximately 0.1, and variance due to common familial environment (VEC/VP) was -0.3. Analysis of families of selected twin children and their parents resulted in two estimates of heritability: approximately 0.7 and 0.3, rho being 0.34 and 0.04, and VEC/VP being 0.04 and 0.34, respectively. Regression of IQ (y) on corrected and standardized plasma uric acid level (x) in the twin children was y = 5.56x + 123, correlation being 0.334 (p less than 0.025). The result indicates a genetic basis of blood uric acid level, which may have resulted from polymorphisms in purine metabolism pathway, end product of which is uric acid in man. The significant correlation between plasma uric acid level and IQ suggests a contribution of partly common gene loci to the two quantitative traits.
应用新设计的模型，在由双胞胎父母、配偶和子女组成的家庭中，对年龄和性别进行校正并标准化后的血浆尿酸水平遗传力（VA/VP）估计为0.8。由于共同基因型导致的配偶间相关性（rho）约为0.1，由于共同家庭环境导致的方差（VEC/VP）为 -0.3。对选定双胞胎子女及其父母的家庭进行分析得出了两个遗传力估计值：约为0.7和0.3，rho分别为0.34和0.04，VEC/VP分别为0.04和0.34。双胞胎子女中经校正和标准化后的血浆尿酸水平（x）对智商（y）的回归方程为y = 5.56x + 123，相关性为0.334（p小于0.025）。结果表明血尿酸水平存在遗传基础，这可能是由嘌呤代谢途径中的多态性导致的，在人类中嘌呤代谢途径的终产物是尿酸。血浆尿酸水平与智商之间的显著相关性表明部分共同基因座对这两个数量性状有影响。
