抑郁症、犯罪行为与酒精中毒相关的精神病理学：一项双胞胎研究的证据。
Depression, criminality and psychopathology associated with alcoholism: evidence from a twin study.
作者信息
Gurling H M, Oppenheim B E, Murray R M
出版信息
Acta Genet Med Gemellol (Roma). 1984;33(2):333-9. doi: 10.1017/s0001566000007376.
A study of 74 twin pairs with alcoholic probands from the Maudsley Hospital is reported. Pairwise concordance for alcoholism as categorised by the SADS-L Research Diagnostic Criteria is similar in MZ twins (29%, 8/22) and DZ twins (33%, 13/39). Concordance for all diagnoses other than alcoholism is however significantly greater in MZ twins (48%, 13/27) than DZ twins (21%, 8/39, P less than 0.001). Concordance in MZ and DZ twins for all diagnoses other than alcoholism, including depression, did not coincide with concordance for alcoholism. Data on criminality revealed that 21% (32/148) of the twin sample had non-alcohol, non-traffic offences on record at the UK Home Office. Of the 32 with criminal records, 28 were alcoholic probands and pairwise concordance for criminality was found in only 1 MZ and 2 DZ pairs.
本文报告了一项对来自莫兹利医院的74对有酗酒先证者的双胞胎的研究。根据SADS-L研究诊断标准分类的酒精中毒的成对一致性在同卵双胞胎（29%，8/22）和异卵双胞胎（33%，13/39）中相似。然而，除酒精中毒外的所有诊断的一致性在同卵双胞胎（48%，13/27）中显著高于异卵双胞胎（21%，8/39，P小于0.001）。同卵和异卵双胞胎中除酒精中毒外的所有诊断（包括抑郁症）的一致性与酒精中毒的一致性不一致。犯罪数据显示，21%（32/148）的双胞胎样本在英国内政部有非酒精、非交通犯罪记录。在32名有犯罪记录的人中，28名是酗酒先证者，仅在1对同卵双胞胎和2对异卵双胞胎中发现了犯罪的成对一致性。
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