Caprioli J, Sears M
Exp Eye Res. 1984 Jul;39(1):47-50. doi: 10.1016/0014-4835(84)90113-1.
Forskolin, a diterpene, a potent and direct stimulator of the catalytic unit of adenylate cyclase, can reduce intraocular pressure when administered topically to rabbit eyes in a 1% suspension. Using an intravitreal plant of fluorescein-dextran, aqueous flow was measured by a modification of the method of Maurice. Forskolin reduces net aqueous flow by 51% compared to the controls. Acetazolamide (25 mg kg-1) administered intravenously reduces net aqueous flow by 45%. Forskolin and acetazolamide together reduce net aqueous flow by 72%, an important additive effect undoubtedly produced by different pathways.
毛喉素是一种二萜类化合物，是腺苷酸环化酶催化单元的强效直接刺激剂，以1%的悬浮液局部应用于兔眼时可降低眼压。使用荧光素 - 葡聚糖的玻璃体内植入物，通过对莫里斯方法的改进来测量房水流量。与对照组相比，毛喉素可使房水净流量降低51%。静脉注射乙酰唑胺（25 mg/kg）可使房水净流量降低45%。毛喉素和乙酰唑胺共同作用可使房水净流量降低72%，这种重要的相加作用无疑是由不同途径产生的。
