Caprioli J, Sears M
Lancet. 1983 Apr 30;1(8331):958-60. doi: 10.1016/s0140-6736(83)92084-6.
Topical ocular application of forskolin, a diterpene that increases intracellular cyclic adenosine monophosphate by stimulating adenylate cyclase directly without cell surface mediation, lowered intraocular pressure (IOP) in rabbits, monkeys, and volunteers who were free from eye disease. In man 50 microliters of a topical suspension of 1% forskolin significantly lowered IOP in 1 h, the effect reaching a peak at 2 h but remaining significant for at least 5 h. Outflow pressure fell by 70% on average. Forskolin and its analogues represent a new class of drugs active against glaucoma which differ in their molecular actions from any previously used drug.
毛喉素是一种二萜类化合物，可通过直接刺激腺苷酸环化酶而不依赖细胞表面介导来增加细胞内环磷酸腺苷，对无眼部疾病的兔、猴和志愿者进行眼部局部应用后，可降低眼压（IOP）。在人体中，50微升1%毛喉素的局部混悬液在1小时内可显著降低眼压，2小时时效果达到峰值，但至少5小时内仍保持显著。流出压力平均下降70%。毛喉素及其类似物代表了一类新型抗青光眼药物，其分子作用与以往使用的任何药物都不同。
