Frances H, Danti S, Puech A J, Simon P
Pharmacol Biochem Behav. 1984 Aug;21(2):313-6. doi: 10.1016/0091-3057(84)90231-4.
The beta-adrenergic agonist clenbuterol decreased interest in food in starved mice, 30 minutes after administration. This effect disappeared after repeated treatment with clenbuterol (0.25 mg/kg, twice daily). Three chronic injections were sufficient to prevent the effect of an acute dose of clenbuterol (0.125 mg/kg) up to 45 hours after treatment.
β-肾上腺素能激动剂克伦特罗在给药30分钟后降低了饥饿小鼠的食欲。在用克伦特罗(0.25毫克/千克,每日两次)重复治疗后,这种作用消失。三次慢性注射足以在治疗后长达45小时内预防急性剂量克伦特罗(0.125毫克/千克)的作用。