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长期给药后,β-肾上腺素能激动剂克伦特罗诱导的咬啮行为减少现象消失。

Disappearance of the decrease in biting behavior induced by clenbuterol, a beta-adrenergic agonist, after chronic administration.

作者信息

Frances H, Danti S, Puech A J, Simon P

出版信息

Pharmacol Biochem Behav. 1984 Aug;21(2):313-6. doi: 10.1016/0091-3057(84)90231-4.

DOI:10.1016/0091-3057(84)90231-4
PMID:6541345
Abstract

The beta-adrenergic agonist clenbuterol decreased interest in food in starved mice, 30 minutes after administration. This effect disappeared after repeated treatment with clenbuterol (0.25 mg/kg, twice daily). Three chronic injections were sufficient to prevent the effect of an acute dose of clenbuterol (0.125 mg/kg) up to 45 hours after treatment.

摘要

β-肾上腺素能激动剂克伦特罗在给药30分钟后降低了饥饿小鼠的食欲。在用克伦特罗(0.25毫克/千克,每日两次)重复治疗后,这种作用消失。三次慢性注射足以在治疗后长达45小时内预防急性剂量克伦特罗(0.125毫克/千克)的作用。

相似文献

1
Disappearance of the decrease in biting behavior induced by clenbuterol, a beta-adrenergic agonist, after chronic administration.长期给药后,β-肾上腺素能激动剂克伦特罗诱导的咬啮行为减少现象消失。
Pharmacol Biochem Behav. 1984 Aug;21(2):313-6. doi: 10.1016/0091-3057(84)90231-4.
2
Tolerance to or facilitation of pharmacological effects induced by chronic treatment with the beta-adrenergic stimulant clenbuterol.对β-肾上腺素能兴奋剂克伦特罗长期治疗所诱导的药理效应的耐受性或促进作用。
J Neural Transm. 1985;62(1-2):65-76. doi: 10.1007/BF01260416.
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Behavioral effects of beta adrenergic agonists and antidepressant drugs after down-regulation of beta-2 adrenergic receptors by clenbuterol.克伦特罗下调β-2肾上腺素能受体后β肾上腺素能激动剂和抗抑郁药物的行为效应
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Repeated treatment with clenbuterol produces desensitization of rat brain beta- and alpha 2-adrenoceptors without changes of alpha 1-adrenoceptors.
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Lesions of the serotonergic system impair the facilitation of but not the tolerance to the effects of chronic clenbuterol administration.血清素能系统的损伤会削弱慢性给予克伦特罗所产生效应的易化作用,但不会削弱其耐受性。
Psychopharmacology (Berl). 1987;91(4):496-9. doi: 10.1007/BF00216017.
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Peripheral mediation of effects of clenbuterol on locomotor and investigatory behavior in rats.克仑特罗对大鼠运动和探究行为影响的外周介导作用
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Effect of clenbuterol on sexual behavior in male rats.克伦特罗对雄性大鼠性行为的影响。
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Reserpine-induced hypothermia: participation of beta 1 and beta 2 adrenergic receptors.利血平诱导的体温过低:β1和β2肾上腺素能受体的参与
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The pharmacological effects of acute and chronic clenbuterol treatments after lesions of central noradrenergic nerve terminals.中枢去甲肾上腺素能神经末梢损伤后急性和慢性克仑特罗治疗的药理作用。
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Does a single priming injection of clenbuterol alter behavioral response to beta-adrenoceptor agonists and antagonists in mice through a time-dependent process?单次注射克伦特罗进行预处理是否会通过时间依赖性过程改变小鼠对β-肾上腺素能受体激动剂和拮抗剂的行为反应?
Eur J Pharmacol. 1985 Sep 10;115(1):91-6. doi: 10.1016/0014-2999(85)90588-6.

引用本文的文献

1
Tolerance to or facilitation of pharmacological effects induced by chronic treatment with the beta-adrenergic stimulant clenbuterol.对β-肾上腺素能兴奋剂克伦特罗长期治疗所诱导的药理效应的耐受性或促进作用。
J Neural Transm. 1985;62(1-2):65-76. doi: 10.1007/BF01260416.
2
Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1).慢性β-肾上腺素能刺激可增加小鼠对麦角新碱的敏感性以及脑内高亲和力5-羟色胺结合位点(5-HT-1)的数量。
J Neural Transm. 1986;67(3-4):215-24. doi: 10.1007/BF01243349.