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氨曲南治疗引起的肠球菌二重感染和定植。

Enterococcal superinfection and colonization with aztreonam therapy.

作者信息

Chandrasekar P H, Smith B R, LeFrock J L, Carr B

出版信息

Antimicrob Agents Chemother. 1984 Aug;26(2):280-2. doi: 10.1128/AAC.26.2.280.

Abstract

Patients were given aztreonam (SQ 26,776) parenterally for the treatment of various gram-negative infections. During or shortly after therapy, 8 (17.8%) of 45 patients became infected with or colonized by enterococcus. These eight cases included eight urinary tract isolates; one of these cases subsequently developed bacteremia. Five patients required further antimicrobial therapy directed against enterococcus. Patients receiving aztreonam are at risk for the development of enterococcal superinfection or colonization.

摘要

患者接受氨曲南(SQ 26,776)静脉注射治疗各种革兰氏阴性菌感染。在治疗期间或治疗后不久,45名患者中有8名(17.8%)感染了肠球菌或被肠球菌定植。这8例包括8株泌尿道分离株;其中1例随后发生了菌血症。5名患者需要针对肠球菌进行进一步的抗菌治疗。接受氨曲南治疗的患者有发生肠球菌二重感染或定植的风险。

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本文引用的文献

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Pharmacokinetics of the monobactam SQ 26,776 after single intravenous doses in healthy subjects.
J Antimicrob Chemother. 1981 Dec;8 Suppl E:131-40. doi: 10.1093/jac/8.suppl_e.131.
4
Pharmacokinetics and tissue penetration of azthreonam.氨曲南的药代动力学及组织穿透性。
Antimicrob Agents Chemother. 1982 Dec;22(6):969-71. doi: 10.1128/AAC.22.6.969.
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Enterococcal infections in patients treated with moxalactam.接受羟羧氧酰胺菌素治疗患者的肠球菌感染
Rev Infect Dis. 1982 Nov-Dec;4 Suppl:S708-11. doi: 10.1093/clinids/4.supplement_3.s708.
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Antibiotic-induced suprainfection.
J Infect Dis. 1969 Jun;119(6):662-5. doi: 10.1093/infdis/119.6.662.

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