Felicio L S, Nelson J F, Finch C E
Biol Reprod. 1984 Oct;31(3):446-53. doi: 10.1095/biolreprod31.3.446.
The of onset of acyclicity and the duration of persistent vaginal cornification (PVC), the predominant postcyclic anovulatory condition, were measured in five cohorts of virgin mice staggered across a 6-yr interval. The average age of cessation of cyclicity varied significantly among cohorts, ranging from 11 to 16 mo of age. Seventy-five percent of the mice entered PVC after ceasing to cycle, the remainder entered directly into a persistent diestrous condition. The duration of PVC, which averaged between 2 and 4 mo, varied markedly among individuals and was inversely related to the age of onset of acyclicity. Consequently, the variance associated with the cessation of cyclicity was about 4-fold greater than that associated with the cessation of PVC. These differing variances suggest that the factors governing ovulatory failure and PVC cessation may differ.
在跨越6年时间间隔交错排列的五组处女小鼠中，测量了无周期性开始的时间以及持续性阴道角质化（PVC）的持续时间，PVC是主要的周期后无排卵状态。各小鼠组间月经周期停止的平均年龄差异显著，范围在11至16月龄之间。75%的小鼠在停止周期性发情后进入PVC阶段，其余小鼠则直接进入持续性动情间期状态。PVC的持续时间平均在2至4个月之间，个体间差异显著，且与无周期性开始的年龄呈负相关。因此，与月经周期停止相关的方差比与PVC停止相关的方差大约大4倍。这些不同的方差表明，控制排卵失败和PVC停止的因素可能不同。
