[近交系C57B1/6和CBA小鼠大脑生物胺水平与血液中乙醇动力学的比较评估]
[Comparative evaluation of the biogenic amine level of the brain and the ethanol kinetics in the blood of inbred C57B1/6 and CBA mice].
作者信息
Khodorova N A, Vlasova N V, Maĭskiĭ A I
出版信息
Biull Eksp Biol Med. 1984 Sep;98(9):284-5.
The kinetics of ethanol in blood and the levels of serotonin, noradrenaline, and dopamine in the cortex of cerebral hemispheres, hypothalamus, thalamus, and brain stem were studied in male C57C1/6 and CBA mice characterized by predisposition and non-predisposition to the development of experimental alcoholism. C57B1/6 mice characterized by predisposition to the development of experimental alcoholism demonstrated a high level of serotonin and noradrenaline in the hypothalamus and brain stem and high rate of ethanol elimination from the blood. CBA mice non-predisposed to the development of experimental alcoholism were characterized by a low level of serotonin and noradrenaline in the hypothalamus and brain stem and by low rate of ethanol elimination from blood.
在具有实验性酒精中毒易感性和非易感性特征的雄性C57C1/6和CBA小鼠中，研究了血液中乙醇的动力学以及大脑半球皮质、下丘脑、丘脑和脑干中血清素、去甲肾上腺素和多巴胺的水平。具有实验性酒精中毒易感性特征的C57B1/6小鼠在下丘脑和脑干中表现出血清素和去甲肾上腺素水平较高，且血液中乙醇消除率较高。不具有实验性酒精中毒易感性的CBA小鼠在下丘脑和脑干中血清素和去甲肾上腺素水平较低，且血液中乙醇消除率较低。
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