Petkov V D, Grakhoska T, Konstantinova E, Petkov V V
Farmakol Toksikol. 1985 May-Jun;48(3):19-22.
In experiments on male albino rats it was established that the aporphine alkaloid 7-hydroxyglaucine injected i.p. at a dose of 1/10 of the LD50 induced many changes in the brain level of biogenic amines. Serotonin content was significantly increased in all brain structures studied (whole brain. cortex, striatum, and hypothalamus) Dopamine level was increased in the whole brain and cortex and was decreased in the hypothalamus; noradrenaline level was increased in the cortex and was decreased in the whole brain and hypothalamus. These effects are thought to be due to the 7-hydroxyglaucine-facilitated transport of amino acids, precursors of biogenic amines, and to neurotransmitter interactions in the different brain structures.
在对雄性白化大鼠的实验中发现，腹腔注射剂量为半数致死量的1/10的阿朴啡生物碱7-羟基青藤碱会引起脑内生物胺水平的许多变化。在所研究的所有脑结构（全脑、皮层、纹状体和下丘脑）中，血清素含量显著增加；全脑和皮层中的多巴胺水平升高，而下丘脑中的多巴胺水平降低；皮层中的去甲肾上腺素水平升高，而全脑和下丘脑中的去甲肾上腺素水平降低。这些作用被认为是由于7-羟基青藤碱促进了生物胺前体氨基酸的转运以及不同脑结构中的神经递质相互作用。
