Ritsner M S, Shmidt I R, Karas' S I
Genetika. 1984 Aug;20(8):1380-6.
Complex genetic-mathematical analysis (component decomposition of the phenotype variance, segregation analysis, estimation of penetrance parameters) of 324 probands' families with neurologic manifestation of spinal osteochondrosis (3437 relatives of I-III degree) has been carried out is shown that the structure of liability to the disease studied is better approximated by semi-continuous phenotype model within the limits of which contribution of genetic factors reaches 80% (63-66% owing to autosomes and 14-17% owing to gonosomes) under considerable influence (20%) of environmental force (14% accidental and 6% systematic).
对324个患有脊髓骨软骨病神经表现的先证者家庭（3437名I - III级亲属）进行了复杂的遗传数学分析（表型方差的成分分解、分离分析、外显率参数估计），结果表明，所研究疾病易感性的结构通过半连续表型模型能得到更好的近似，在该模型范围内，在环境因素（14%为偶然因素，6%为系统因素）相当大的影响（20%）下，遗传因素的贡献达到80%（常染色体占63 - 66%，性染色体占14 - 17%）。
